Accutane (isotretinoin) has been designed for the treatment of severe nodular acne. It works by preventing the formation of pimples. This drug must never be taken by pregnant women as it can cause severe birth defects in babies. Make sure you talk to your doctor before you start taking Accutane and tell him about any medical conditions you have that may prevent you from safely taking Accutane. The following ones are important to report: high triglyceride levels, anorexia nervosa, heart or liver disease, history of suicide attempt, asthma, mental illness, diabetes, osteoporosis, and depression. Your doctor will also be interested to know if you are taking any drugs that have been reported to interact with Accutane - such as phenytoin, dexamethasone, medications for seizures, tetracycline, doxycycline, methylprednisolone, prednisone, minocycline, vitamin A supplements, and demeclocycline. There is no need to worry if you get dryness of the lips, mouth, nose, or skin, joint pain, dizziness, nervousness, back pain, changes in your fingernails, drowsiness, cracking or peeling skin - as those are mild side effects of Accutane that do not need to be reported.